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A second read on your trial, before it reads out.
Encounter applies the same framework shown on the scorecard to trials that haven't reported yet — including yours. We tell you what the structure of your design predicts, where the weak seams are, and which patients the mechanism can actually reach. Two ways to engage: a short directional call, or a full structural read with per-patient stratification, arm-sizing, and the source code to run it yourself.
Two ways to engage
Tier 1
Structural call
A directional call on whether your trial design is structurally positioned to read out. Suitable for go/no-go decisions, competitive intelligence, and early-stage design review.
- Directional call: WIN, FAIL, EQUIVALENT, or SIGNAL
- The named structural reason in two or three sentences
- The closest analog trials with citations
- One critical test to look for in the readout data
- One-page memo, delivered as a PDF
5 business days · single trial · one page
Not included: per-patient stratification, predicted response rates, arm-sizing analysis, enrolment criteria, source code. For those, see the structural read.
Tier 2
Structural read
The full deliverable. A structural classification of your candidate population, predicted response rates per class, arm-sizing implications, and the source code that runs the calculation against your own pre-treatment bulk RNA-seq.
- Per-patient structural classification
- Predicted response rates per class, with confidence intervals
- Arm-sizing analysis under stratified enrolment
- Defensible enrolment criteria with the gene panel and cutoff
- Source code that runs against your own bulk RNA-seq
- 90-minute readout call with the full report
2 weeks · full report · readout call included
Best for: trials already in design where the question is how to structure them to win, not whether to pursue them at all.
Tier 2 in detail — what the structural read delivers
01
A structural classification of your population
Each patient placed in one of the framework's classes — held upstream, past the point of action, or in the addressable window. With confidence intervals.
02
Predicted response rates per class
For your specific drug mechanism. Calibrated against the closest published cohorts. Honest error bars where the data is thin.
03
Arm-sizing implications
If you stratify on the structural call, what sample size do you need to detect a +15pp effect? +20pp? With and without screening cost.
04
A defensible enrolment criterion
If your drug only works on patients in a specific class, the report tells you which gene panel separates them and where to set the cutoff.
05
The method, end to end
The exact panel composition, the threshold logic, the per-marker rationale, and the source code that runs the structural calculation against your own pre-treatment bulk RNA-seq. Public Encounter reports show what the framework concluded; the service delivers the calculation.
Tier 2 process — from brief to delivered report
1
Submit a brief
5 minutes
Fill the form below with the trial details: indication, drug class, phase, the specific question you want answered. No NDA needed — the form covers what we need to scope.
2
Scoping call
Within 2 business days
A 30-minute call to confirm the trial details, share any pre-existing data we should look at, and align on what the deliverable should answer. After the call you receive a fixed-fee proposal.
3
Structural read
2 weeks
We pull the relevant published cohorts, run the framework against your trial's design, and produce the report. You get a draft after 10 business days for review.
4
Final report + briefing
After review
Final PDF delivered, plus a 60-minute briefing call where we walk your team through the call, the reasoning, and the trial-design implications. You can use the report internally however you want.
